Chromosomal and genomic changes in lung cancer

Lung Changes in Shock

In the very beginning stage of the lung changes are Perivascular, capillary wall edema, thickening of the interstitial, lymph and vascular dilatation.  In the late stage of the shock the following changes will occuree  Microthromboses of the lung capillary, polynulcear in­filtration into the interstitial, the existence of polynu­clear in the alveoli, proliferation of interstitial mesenchy­ma,...

Genomic approaches to lung cancer.

The last decade has seen remarkable success in clinical targeting of activated oncogenes in cancer. We have applied gene expression profiling, high-density single-nucleotide polymorphism arrays, and systematic resequencing of genes to identify novel oncogenes and signaling pathways in lung cancer that might represent therapeutic targets. Systematic resequencing of tyrosine kinase genes has led ...

Genomic approaches to research in lung cancer

The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opportunities for improving our understanding of complex diseases such as lung cancer. In particular, we should expect to witness a rapid increase in the rate of discovery of genes involved i...

Hidden Markov model for defining genomic changes in lung cancer using gene expression data.

The study of gene expression patterns in relationship to chromosomal position, the "transcriptome map," has become an area of active research and has revealed unexpected chromosomal regions within which gene expression levels are highly correlated. In cancer research, these regional changes in gene expression that may result from alterations at the chromosome level such as gene amplification or...

translating hispanic genomic factors in lung cancer into clinical practice: egfr testing for improved outcomes